EU patent no. EP2170961
USA pat. pend.
amalian – cross-linked hyaluronic acid with the pioneering CIS technology
Core = cross-linked HA - Shell = non-cross-linked HA
The unique CIS technology makes amalian different from other products made of cross-linked hyaluronic acid. This inventive “core-in-shell” structure forms a stable core of highly cross-linked hyaluronic acid, surrounded by long chains of non-cross-linked hyaluronic acid like a protective shell. This structure delays the degradation of hyaluronic acid by hyluronidase, and helps prolonging the effects of treatment. The CIS technology also has a crucial positive impact on viscoelasticity: When no pressure is applied, the gel is viscous and exhibits excellent augmentative effects, but when injected into the skin it will liquefy under the injection stress. Once injected, the hyaluronic acid will “bounce back” into its original viscous shape, which makes it a perfect, persistent wrinkle filler for dermal tissues.