Toxicology
| Test | Product | Method | Result |
|---|---|---|---|
| Cytotoxicity | amalian expert I premium amalian expert III volume | In vitro cell proliferation assay, L929 cells, BCA staining;agarose overlay, L929 cells | non-cytotoxic |
| Sensitisation | amalian expert I premiumamalian expert III volume | Murine local lymph node assay (MLLA) | non-sensitizing |
| Irritation | amalian expert I premiumamalian expert III volume | Subcutaneous reactivity | non-irritant |
| Systemic (acute) toxicity | amalian expert I premium amalian expert III volume | Injection test for detection of acute systemic reactions | non-toxic, no loss of weight |
| Subacute / subchronic toxicity | amalian expert I premium amalian expert III volume | 4-week biocompatibility + toxicity | non-toxic |
| Genotoxicity | amalian expert I premium amalian expert III volume | In vitro mouse lymphoma assay, L5178Y | no induced mutagenic / clastogenic cell response |
Mutagenicity | amalian expert I premium amalian expert III volume | Ames assay, 5 Salmonella strains In vivo mouse micronucleus assay (bone marrow) | non-mutagenic non-mutagenic |
| Implantation | amalian expert I premium amalian expert III volume | Intramuscular implantation test (rabbit): | non-irritating |